A typical passenger vehicle weighs 3,000 pounds while pickup trucks tend to weigh well over 4,000 pounds. Accidents tend to happen in both types of vehicles in roughly the same amounts each year, but there are some differences.
First, as pickup trucks usually weigh more than cars, there may be fewer serious injuries with pickups simply because they are heavier.
However, it should be noted that pickup trucks usually have a higher center of gravity so they can tend to roll in an accident. Vehicles that are taller will always have a greater chance of rolling. Rollovers can lead to very serious and fatal accidents because there is a higher chance of an occupant being ejected from the vehicle.
Another common difference with pickup truck accidents is that many of them are used by companies to do various outdoor work. Generally speaking, pickup trucks are more likely to get into accidents with bikers and pedestrians.